triethylamine; hydrazine in isopropyl alcohol 2 - 3 h; Heating / reflux;

1: With hydrogen bromide in water Heating / reflux; 2: With sodium hydroxide in water T=10°C;

1: trans-4-amino-cyclohexanol With acetic anhydride in N,N-dimethyl-formamide T=10 - 15°C; 2: With Jone's reagent in acetone T=10 - 15°C; 3 h; 3: thiourea With sodium hydroxide; water; hydrogen bromide; bromine Product distribution / selectivity; more than 3 stages;

in acetic acid T=80°C; 3 h; Product distribution / selectivity;

1.1: bromine; acetic acid / 0.75 h / 25 - 35 °C 1.2: 3 h / Reflux 2.1: water; sulfuric acid / 10 h / Reflux 2.2: 1.5 h / 0 - 30 °C View Scheme

water; hydrogen bromide 15 h; Reflux;

2: 84 percent / triethylamine / tetrahydrofuran / 2 h / -5 °C View Scheme

optical resolution with chiral tartaric acid;

暂无反应条件数据

1.1: water / 70 °C / Reflux; Resolution of racemate 2.1: hydrogenchloride / water / carbon treatment 2.2: 1.5 h / 25 - 30 °C 3.1: triethylamine / methanol / 1.5 h / 10 - 20 °C 4.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 4 h / 0 - 50 °C 4.2: 0.17 h / 10 °C 5.1: hydrogenchloride / water; methanol / 0.75 h / 25 - 30 °C View Scheme