5-甲氧基吲哚-3-甲醛合成路线 （共 40 条）
反应条件
1.1: t-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 1.2: pentane; tetrahydrofuran / 0.25 h / -78 °C 2.1: 205 mg / Bu4NF / tetrahydrofuran / 0.17 h / 20 °C View Scheme
参考文献
Synthesis, , # 2 p. 267 - 275
反应条件
1: 77 percent / Cu; quinoline / Heating 2: 90 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 99 percent / aq. NaOH / Heating 2: 77 percent / Cu; quinoline / Heating 3: 90 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium 1) -10 degC, THF, 2) 0 degC, 20 min; Yield given. Multistep reaction;
参考文献
Bartoli, Giuseppe; Palmieri, Gianni; Petrini, Marino
Tetrahedron, 1990 , vol. 46, # 4 p. 1379 - 1384
反应条件
acetic acid 2.5 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 18 p. 5909 - 5914
参考文献
Journal of the Chemical Society, , vol. 125, p. 313
反应条件
sodium hydride in dimethyl sulfoxide T=20°C; 0.5 h;
参考文献
Sharma, Kavita; Iyer, Aishwarya; Sengupta, Kundan; Chakrapani, Harinath
Organic Letters, 2013 , vol. 15, # 11 p. 2636 - 2639
反应条件
sodium hydroxide in water 12 h; Ambient temperature;
参考文献
Reimann; Hargasser
Archiv der Pharmazie, 1988 , vol. 321, # 11 p. 823 - 826
反应条件
sodium carbonate in neat (no solvent) T=20°C; 0.25 h;
参考文献
Thirupathi; Venkatanarayana; Dubey; Bharathi Kumari
Medicinal Chemistry Research, 2014 , vol. 23, # 3 p. 1569 - 1580
反应条件
1: NH4OAc / 70 °C 2: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 338, # 2-3 p. 67 - 73
