5-甲氧基吲哚-3-甲醛合成路线 （共 40 条）
反应条件
1: 1.08 g / MeI / methanol; H2O / 10 h / 20 °C 2: 95 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 3 h / 20 °C 3: NaH / dimethylformamide / 4 h / 20 °C 4: (n-Bu)4NF / tetrahydrofuran / 8 h / 65 °C 5: LAH / diethyl ether; benzene / 0.75 h / 20 °C View Scheme
参考文献
Tsotinis, Andrew; Vlachou, Margarita; Papahatjis, Demetris P.; Calogeropoulou, Theodora; Nikas, Spyros P.; Garratt, Peter J.; Piccio, Vincent; Vonhoff, Stefan; Davidson, Kathryn; Teh, Muy-Teck; Sugden, David
Journal of Medicinal Chemistry, 2006 , vol. 49, # 12 p. 3509 - 3519
反应条件
ammonium acetate in benzene Henry reaction; Reflux;
参考文献
Zhang, Pu Yong; Wan, Sheng Biao; Ren, Su Mei; Jiang, Tao
Chinese Chemical Letters, 2010 , vol. 21, # 11 p. 1307 - 1309
反应条件
1: 77 percent / sodium acetate, nitroethane / acetic acid / 10 h / Heating 2: H2, NH4OH / W-2 Raney nickel / ethanol / 2068.6 Torr View Scheme
参考文献
Klohr, Steven E.; Cassady, John M.
Synthetic Communications, 1988 , vol. 18, # 7 p. 671 - 674
反应条件
1: 1.) thallium(III) trifluoroacetate, 2.) aq. potassium iodide / 1) CF3CO2H, 2 h, 30 deg C; 2) 15 min 2: 22 percent / copper iodide / dimethylformamide / 0.75 h / 110 - 120 °C View Scheme
参考文献
Moody, Christopher J.; Swann, Elizabeth
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 21 p. 2561 - 2566
反应条件
in water 2 h; Heating / reflux;
参考文献
EP1955998 A1, ;
Page/Page column 3 ;
反应条件
palladium diacetate; potassium carbonate in ethyl acetate T=150°C; P=12929 Torr; 0.833333 h; Microwave irradiationMolecular sieve;
参考文献
Akanksha; Maiti, Debabrata
Green Chemistry, 2012 , vol. 14, # 8 p. 2314 - 2320
反应条件
1: 1.08 g / MeI / methanol; H2O / 10 h / 20 °C 2: 0.53 g / aq. KOH / dimethylformamide / 0 - 20 °C View Scheme
参考文献
Tsotinis, Andrew; Vlachou, Margarita; Papahatjis, Demetris P.; Calogeropoulou, Theodora; Nikas, Spyros P.; Garratt, Peter J.; Piccio, Vincent; Vonhoff, Stefan; Davidson, Kathryn; Teh, Muy-Teck; Sugden, David
Journal of Medicinal Chemistry, 2006 , vol. 49, # 12 p. 3509 - 3519
反应条件
1: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, RT, 1 h 2: 84 percent / HNO3(conc.), AcOH / 1.) 0 deg C, 3 h, 2.) RT, 16 h View Scheme
参考文献
Sharma, Kavita; Iyer, Aishwarya; Sengupta, Kundan; Chakrapani, Harinath
Organic Letters, 2013 , vol. 15, # 11 p. 2636 - 2639
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; Schlenk technique;
参考文献
Beaud, Rodolphe; Guillot, Regis; Kouklovsky, Cyrille; Vincent, Guillaume
Chemistry - A European Journal, 2014 , vol. 20, # 24 p. 7492 - 7500
反应条件
1,3-dimethyl-imidazolidin-2-one; sodium hexamethyldisilazane in tetrahydrofuran T=185°C; 12 h;
参考文献
European Journal of Organic Chemistry, , # 11 p. 2513 - 2516
