5-甲氧基吲哚-3-甲醛合成路线 （共 40 条）
反应条件
methyl iodide in methanol; water T=20°C; 10 h;
参考文献
Tsotinis, Andrew; Vlachou, Margarita; Papahatjis, Demetris P.; Calogeropoulou, Theodora; Nikas, Spyros P.; Garratt, Peter J.; Piccio, Vincent; Vonhoff, Stefan; Davidson, Kathryn; Teh, Muy-Teck; Sugden, David
Journal of Medicinal Chemistry, 2006 , vol. 49, # 12 p. 3509 - 3519
反应条件
sodium tetrahydroborate in methanol; formamide
参考文献
Kwon, Tae Hoon; Yoon, Ik Hwan; Shin, Ji-Sun; Lee, Young Hun; Kwon, Bong Jin; Lee, Kyung-Tae; Lee, Yong Sup
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2571 - 2574
反应条件
1: 5-methoxyindole-3-carboxaldehyde With sodium hydroxide in dichloromethane
T=20°C;
2: 4methoxybenzenesulfonyl chloride in dichloromethane
T=20°C;
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 20 °C
1.2: 95 percent / CH2Cl2 / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 65 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 20 °C
1.2: 95 percent / CH2Cl2 / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 62 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 83 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 20 °C
1.2: 95 percent / CH2Cl2 / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 84 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 20 °C
1.2: 95 percent / CH2Cl2 / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 20 °C
1.2: 95 percent / CH2Cl2 / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 71 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 94 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1: piperidine; acetic acid / benzene / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / Reflux
View Scheme
参考文献
Nirogi, Ramakrishna V.S.; Kambhampati, Ramasastri; Kothmirkar, Prabhakar; Konda, Jagadishbabu; Bandyala, Thrinath Reddy; Gudla, Parandhama; Arepalli, Sobhanadri; Gangadasari, Narasimhareddy P.; Shinde, Anil K.; Deshpande, Amol D.; Dwarampudi, Adireddy; Chindhe, Anil K.; Dubey, Pramod Kumar
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 3 p. 443 - 450
反应条件
1: 86 percent / Et3N, DMAP / CH2Cl2 / 1 h / Ambient temperature
2: 54 percent / m-chloroperbenzoic acid / CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Bourlot; Desarbre; Merour
Synthesis, 1994 , # 4 p. 411 - 416
