3,3-二乙氧基丙酸乙酯合成路线 （共 81 条）
反应条件
1: β,β-diethoxypropionic acid ethyl ester; formic acid ethyl ester With sodium hydride in diethyl ether; ethanol T=0 - 20°C; 15 h; 2: 2-methyl-2-thiopseudourea sulfate With sodium acetate in N,N-dimethyl-formamide T=85°C; 48 h;
参考文献
Hamblett, Christopher; Mampreian, Dawn M.; Methot, Joey L.; Miller, Thomas; Sloman, David L.; Stanton, Matthew G.; Wilson, Kevin
Patent: US2009/105264 A1, 2009 ;
Location in patent: Page/Page column 33 ;
US 20090105264 A1
反应条件
1: With water; sodium hydroxide T=110°C; 1.25 h; 2: With hydrogenchloride in water T=0°C;
参考文献
Esteve Química, S.A.
Patent: EP2418192 A1, 2012 ;
Location in patent: Page/Page column 26 ;
反应条件
1: 100 percent / trifluoroacetic acid, water / CH2Cl2 / 2 h / Ambient temperature 2: 98 percent / 1 N sodium acetate buffer, pH 5.4 / ethanol; H2O / 1 h / Ambient temperature View Scheme
参考文献
Lu; Miet; Kunesch; Poisson
Tetrahedron Asymmetry, 1990 , vol. 1, # 10 p. 707 - 710
反应条件
toluene-4-sulfonic acid T=140 - 180°C;
参考文献
Kloetzer,W.
Monatshefte fuer Chemie, 1964 , vol. 95, p. 1729 - 1739
参考文献
Cavalieri; Bendich
Journal of the American Chemical Society, 1950 , vol. 72, p. 2587,2593
反应条件
T=180°C; 0.0833333 h;
参考文献
ARGENTA DISCOVERY LIMITED
Patent: WO2004/13130 A1, 2004 ;
Location in patent: Page 181 ;
反应条件
1: formic acid ethyl ester With sodium hydride in diethyl ether T=0°C; 2: β,β-diethoxypropionic acid ethyl ester in diethyl ether T=0°C; 48 h; 3: 1-Imino-ethanamine hydrochloride in diethyl ether T=20°C; 24 h;
参考文献
EP1557411 A1, ;
Page/Page column 15 ;
反应条件
titanium tetrachloride in dichloromethane
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 13 p. 2435 - 2437
反应条件
1: aqueous NH3 2: P2O5; triethylamine; benzene View Scheme
参考文献
McElvain; Clarke
Journal of the American Chemical Society, 1947 , vol. 69, p. 2660
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=10 - 20°C; 1 h; 2: With water in tetrahydrofuran 2 h; Product distribution / selectivity;
参考文献
NOF CORPORATION
Patent: US2012/277477 A1, 2012 ;
Location in patent: Page/Page column 5 ;
