3,3-二乙氧基丙酸乙酯合成路线 （共 81 条）
反应条件
SnCl2·2H2O in ethanol
T=90°C; reductive Friedlander reaction; 4 h; Inert atmosphere;
参考文献
Venkatesan, Hariharan; Hocutt, Frances M.; Jones, Todd K.; Rabinowitz, Michael H.
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3488 - 3491
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=-78 - 20°C;
参考文献
Torrado, Alicia; Lamas, Carlos; Agejas, Javier; Jimenez, Alma; Diaz, Nuria; Gilmore, Jeremy; Boot, John; Findlay, Jeremy; Hayhurst, Lorna; Wallace, Louise; Broadmore, Richard; Tomlinson, Rosemarie
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 20 p. 5277 - 5295
反应条件
sodium
T=0 - 20°C; 48 h;
参考文献
AVEXA LIMITED
Patent: WO2007/124546 A1, 2007 ;
Location in patent: Page/Page column 61 ;
反应条件
anhydrous iron chloride in ethanol; acetic acid
T=90°C; 6 h;
参考文献
Maeda, Sayuki; Obora, Yasushi; Ishii, Yasutaka
European Journal of Organic Chemistry, 2009 , # 24 p. 4067 - 4072
反应条件
anhydrous iron chloride in ethanol; acetic acid
T=90°C; 15 h;
参考文献
Maeda, Sayuki; Obora, Yasushi; Ishii, Yasutaka
European Journal of Organic Chemistry, 2009 , # 24 p. 4067 - 4072
反应条件
gadolinium(III) chloride hexahydrate in ethanol; acetic acid
T=90°C; 6 h;
参考文献
Maeda, Sayuki; Obora, Yasushi; Ishii, Yasutaka
European Journal of Organic Chemistry, 2009 , # 24 p. 4067 - 4072
反应条件
anhydrous iron chloride in ethanol; acetic acid
T=90°C; 15 h;
参考文献
Maeda, Sayuki; Obora, Yasushi; Ishii, Yasutaka
European Journal of Organic Chemistry, 2009 , # 24 p. 4067 - 4072
反应条件
anhydrous iron chloride in ethanol; acetic acid
T=90°C; 15 h;
参考文献
Maeda, Sayuki; Obora, Yasushi; Ishii, Yasutaka
European Journal of Organic Chemistry, 2009 , # 24 p. 4067 - 4072
反应条件
aluminium trichloride; ethylene glycol
Entfernen des entstehenden Aethanols;
参考文献
Croxall et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2741
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Rohm and Haas Co.
Patent: US2500155 , 1948 ;
反应条件
1: TFA / CH2Cl2; H2O / 20 °C
2: 58 percent / NaOAc / ethanol; H2O
3: 67 percent / SOCl2 / 0 - 60 °C
View Scheme
参考文献
Tripathy, Rabindranath; Ghose, Arup; Singh, Jasbir; Bacon, Edward R.; Angeles, Thelma S.; Yang, Shi X.; Albom, Mark S.; Aimone, Lisa D.; Herman, Joseph L.; Mallamo, John P.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1793 - 1798
