4-(4-吡啶)苯甲酸甲酯合成路线 （共 17 条）
反应条件
sodium carbonate; bis-triphenylphosphine-palladium(II) chloride in ethylene glycol dimethyl ether; water T=175°C; Suzuki reaction; 0.166667 h; Microwave irradiation;
参考文献
Drewry, David Harold; Jung, David Kendall; Linn, James Andrew; Hunter, Robert Neil; Lee, Dennis; Stavenger, Robert A.; Sehon, Clark
Patent: US2008/275062 A1, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water Suzuki Coupling;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 73 ;
反应条件
sulfuric acid T=20°C; 3 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577302 A1, 2005 ;
Location in patent: Page/Page column 98 ;
反应条件
potassium hydroxide; tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 3.5 h; Heating;
参考文献
Ishikura; Ohta; Terashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4755 - 4763
反应条件
1: 4-hydroxy-pyridine With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane; N,N-dimethyl-formamide T=100°C; 3 h; Inert atmosphere; 2: (4-methoxycarbonylphenyl)-boronic acid With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane; N,N-dimethyl-formamide T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Huang, Jie; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2011 , vol. 17, # 14 p. 4038 - 4042
反应条件
tetrakis(triphenylphosphine) palladium(0); KF*2H2O in ethylene glycol dimethyl ether; ethanol; water T=110°C; Suzuki Coupling; 0.833333 h; Microwave irradiation;
参考文献
Wu, Jiahui; Zhang, Dengyou; Chen, Lei; Li, Jianneng; Wang, Jianling; Ning, Chengqing; Yu, Niefang; Zhao, Fei; Chen, Dongying; Chen, Xiaoyan; Chen, Kaixian; Jiang, Hualiang; Liu, Hong; Liu, Dongxiang
Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 761 - 780
反应条件
palladium on activated charcoal in 1,3,5-trimethyl-benzene T=160°C; 6 h;
参考文献
Matsushita; Sakamoto; Murakami; Matsui
Synthetic Communications, 1994 , vol. 24, # 22 p. 3307 - 3313
反应条件
tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate in water; toluene 24 h; Heating;
参考文献
Quan; Wityak; Dominguez; Duncia; Kettner; Ellis; Liauw; Park; Santella; Knabb; Thoolen; Weber; Wexler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1595 - 1600
反应条件
1: 81 percent / Et3N / CH2Cl2 / 96 h / -78 - 25 °C 2: 71 percent / Pd(PPh3)4, Bu4NBr, K2CO3 / toluene; H2O / 24 h / Heating View Scheme
参考文献
Quan; Wityak; Dominguez; Duncia; Kettner; Ellis; Liauw; Park; Santella; Knabb; Thoolen; Weber; Wexler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1595 - 1600
反应条件
1: 39 percent / CH3COCl / 24 h / 0 - 25 °C 2: 81 percent / Et3N / CH2Cl2 / 96 h / -78 - 25 °C 3: 71 percent / Pd(PPh3)4, Bu4NBr, K2CO3 / toluene; H2O / 24 h / Heating View Scheme
参考文献
Quan; Wityak; Dominguez; Duncia; Kettner; Ellis; Liauw; Park; Santella; Knabb; Thoolen; Weber; Wexler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1595 - 1600
