[5-(氯甲基)吡啶-2-基]氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0 - 20°C; 12.5 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.
Patent: WO2013/59587 A1, 2013 ;
Location in patent: Page/Page column 207 ;
反应条件
1: thionyl chloride / 12 h / 0 °C / |Reflux 2: 4-(N,N-dimethlyamino)pyridine / tert-butyl alcohol; acetone / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 6.5 h / 0 °C 4: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran / 12.5 h / 0 - 20 °C View Scheme
参考文献
SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.
Patent: WO2013/59587 A1, 2013 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tert-butyl alcohol; acetone / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 6.5 h / 0 °C 3: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran / 12.5 h / 0 - 20 °C View Scheme
参考文献
SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.
Patent: WO2013/59587 A1, 2013 ;
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 6.5 h / 0 °C 2: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran / 12.5 h / 0 - 20 °C View Scheme
参考文献
SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.
Patent: WO2013/59587 A1, 2013 ;
