4-氯-2-甲基吡啶-3-甲醛合成路线 （共 2 条）
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate in 1,4-dioxane; water T=100°C; Suzuki Coupling; 18 h;
参考文献
Bristol-Myers Squibb Company; Vrudhula, Vivekananda M.; Pan, Senliang; Rajamani, Ramkumar; Macor, John E.; Bronson, Joanne J.; Dzierba, Carolyn Diane; Nara, Susheel Jethanand; Karatholuvhu, Maheswaran Sivasamban
Patent: US2013/237555 A1, 2013 ;
Location in patent: Paragraph 0274 ;
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -78 °C 1.2: 1 h / -78 - 20 °C 2.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 18 h / 100 °C View Scheme
参考文献
Bristol-Myers Squibb Company; Vrudhula, Vivekananda M.; Pan, Senliang; Rajamani, Ramkumar; Macor, John E.; Bronson, Joanne J.; Dzierba, Carolyn Diane; Nara, Susheel Jethanand; Karatholuvhu, Maheswaran Sivasamban
Patent: US2013/237555 A1, 2013 ;
