trichlorophosphate T=100°C; 14 h; Inert atmosphere;

1.1: trichlorophosphate / 2 h / |Reflux 1.2: 0 - 20 °C 2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; ethylene glycol dimethyl ether / 85 °C / |Inert atmosphere View Scheme

1: 4-chloro-6-methylnicotinic acid With trichlorophosphate 2 h; Reflux; 2: methanol T=0 - 20°C;