4-氯-6-(三氟甲基)烟酸合成路线 （共 3 条）
反应条件
1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran T=-78 - -30°C; 1.5 h; 2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran T=-78°C; 3 h; 3: With ammonium chloride in tetrahydrofuran T=-78 - 20°C; 0.333333 h;
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; GREUL, Jörg, Nico; MANSFIELD, Darren; FÜSSLEIN, Martin; RIECK, Heiko; RIEDRICH, Matthias; RODEFELD, Lars; KATHER, Kristian; MALSAM, Olga; LÖSEL, Peter; VOERSTE, Arnd; SCHWARZ, Hans-Georg; ILG, Kerstin; GÖRGENS, Ulrich; CARLES, Lionel; COQUERON, Pierrre-Yves; DESBORDES, Philippe; MERESSE, Philippe
Patent: WO2013/64460 A1, 2013 ;
Location in patent: Page/Page column 120; 121 ;
反应条件
borane-THF in tetrahydrofuran T=20°C; Cooling with ice;
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; GREUL, Jörg, Nico; MANSFIELD, Darren; FÜSSLEIN, Martin; RIECK, Heiko; RIEDRICH, Matthias; RODEFELD, Lars; KATHER, Kristian; MALSAM, Olga; LÖSEL, Peter; VOERSTE, Arnd; SCHWARZ, Hans-Georg; ILG, Kerstin; GÖRGENS, Ulrich; CARLES, Lionel; COQUERON, Pierrre-Yves; DESBORDES, Philippe; MERESSE, Philippe
Patent: WO2013/64460 A1, 2013 ;
Location in patent: Page/Page column 121; 122 ;
反应条件
1: borane-THF / tetrahydrofuran / 20 °C / |Cooling with ice 2: thionyl chloride / 1 h / |Cooling with ice; |Reflux View Scheme
