(+)-(6R)-2,6-二氨基-4,5,6,7-四氢苯并噻唑合成路线 (共 4 条)
反应条件
optical resolution with chiral tartaric acid;
参考文献
Bioorg. Med. Chem. Lett., , vol. 14, # 12 p. 3251 - 3256
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498
反应条件
triethylamine in tetrahydrofuran T=-5°C; 2 h;
参考文献
Schneider, Claus S.; Mierau, Joachim
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 494 - 498
反应条件
1: 84 percent / triethylamine / tetrahydrofuran / 2 h / -5 °C 2: borane-tetrahydrofuran complex / tetrahydrofuran / 1 h / 50 °C View Scheme
参考文献
BIOGEN IDEC MA INC.; CHEN, Weirong; HUMORA, Michael; KWOK, Daw-long, Albert; KIESMAN, William, F.; IRDAM, Erwin, Ayandra
Patent: WO2013/96816 A1, 2013 ;