6-(叔丁氧基羰基氨基)-2,3-二甲氧基苯甲酸合成路线 （共 6 条）
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran; dichloromethane; water
参考文献
Ortho Pharmaceutical Corporation
Patent: US4617417 A1, 1986 ;
反应条件
1: N-Boc-3,4-dimethoxylaniline With n-butyllithium in tetrahydrofuran T=-78 - -10°C; 2 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran T=20°C; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; water pH=1 - 2; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
Location in patent: Page/Page column 192 ;
反应条件
1.1: tetrahydrofuran / 2 h / |Inert atmosphere; |Reflux 2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 - -10 °C / |Inert atmosphere 2.2: 20 °C / |Inert atmosphere 2.3: pH 1 - 2 / |Inert atmosphere View Scheme
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
反应条件
1.1: tetrahydrofuran / 2 h / |Inert atmosphere; |Reflux 2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 - -10 °C / |Inert atmosphere 2.2: 20 °C / |Inert atmosphere 2.3: pH 1 - 2 / |Inert atmosphere View Scheme
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
反应条件
tert.-butyl lithium 1.) hexane, THF, -60 to -20 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bengtsson, Stefan; Hoegberg, Thomas
Journal of Organic Chemistry, 1989 , vol. 54, # 19 p. 4549 - 4553
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 3 h; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
Location in patent: Page/Page column 192; 193 ;
