5-溴-2-氯-4-(甲氧基羰基)苯甲酸合成路线 （共 6 条）
反应条件
1: With 18-crown-6 ether in water; tert-butyl alcohol T=55°C; Heating / reflux; 2: With hydrogenchloride in water T=0 - 5°C; pH=1;
参考文献
Lv, Binhua; Xu, Baihua; Feng, Yan; Peng, Kun; Xu, Ge; Du, Jiyan; Zhang, Lili; Zhang, Wenbin; Zhang, Ting; Zhu, Liangcheng; Ding, Haifeng; Sheng, Zelin; Welihinda, Ajith; Seed, Brian; Chen, Yuanwei
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6877 - 6881
反应条件
1.1: N-bromosuccinmide / N,N-dimethyl-formamide / 2 h / 0 - 15 °C / |Inert atmosphere 2.1: thionyl chloride / 6 h / 0 - 5 °C / |Reflux 3.1: sodium nitrite; hydrogenchloride / water; 1,4-dioxane / 2 h / -10 - 0 °C 3.2: 0.67 h / 20 °C 4.1: sulfuric acid; tetrabutylammomium bromide; RuCl3; sodium hypochlorite / 1,2-dichloro-ethane; water / 6 h / pH 9 View Scheme
参考文献
Liu, Yong-Hai; Fu, Ting-Ming; Ou, Chun-Yan; Fan, Wen-Ling; Peng, Guo-Ping
Chinese Chemical Letters, 2013 , vol. 24, # 2 p. 131 - 133
反应条件
1.1: thionyl chloride / 6 h / 0 - 5 °C / |Reflux 2.1: sodium nitrite; hydrogenchloride / water; 1,4-dioxane / 2 h / -10 - 0 °C 2.2: 0.67 h / 20 °C 3.1: sulfuric acid; tetrabutylammomium bromide; RuCl3; sodium hypochlorite / 1,2-dichloro-ethane; water / 6 h / pH 9 View Scheme
参考文献
Liu, Yong-Hai; Fu, Ting-Ming; Ou, Chun-Yan; Fan, Wen-Ling; Peng, Guo-Ping
Chinese Chemical Letters, 2013 , vol. 24, # 2 p. 131 - 133
反应条件
1.1: sodium nitrite; hydrogenchloride / water; 1,4-dioxane / 2 h / -10 - 0 °C 1.2: 0.67 h / 20 °C 2.1: sulfuric acid; tetrabutylammomium bromide; RuCl3; sodium hypochlorite / 1,2-dichloro-ethane; water / 6 h / pH 9 View Scheme
参考文献
Liu, Yong-Hai; Fu, Ting-Ming; Ou, Chun-Yan; Fan, Wen-Ling; Peng, Guo-Ping
Chinese Chemical Letters, 2013 , vol. 24, # 2 p. 131 - 133
反应条件
1: N-chloro-succinimide / tetrachloromethane / 80 °C 2: thionyl chloride / |Reflux 3: potassium permanganate; 18-crown-6 ether; water / tert-butyl alcohol / |Reflux View Scheme
参考文献
Liu, Yong-Hai; Fu, Ting-Ming; Ou, Chun-Yan; Fan, Wen-Ling; Peng, Guo-Ping
Chinese Chemical Letters, 2013 , vol. 24, # 2 p. 131 - 133
反应条件
1: thionyl chloride / |Reflux 2: potassium permanganate; 18-crown-6 ether; water / tert-butyl alcohol / |Reflux View Scheme
参考文献
Liu, Yong-Hai; Fu, Ting-Ming; Ou, Chun-Yan; Fan, Wen-Ling; Peng, Guo-Ping
Chinese Chemical Letters, 2013 , vol. 24, # 2 p. 131 - 133
