4-(氯甲基)-5-甲基-1-(三苯基甲基)-1H-咪唑合成路线 （共 5 条）
反应条件
thionyl chloride in dichloromethane; N,N-dimethyl-formamide T=0°C; 0.25 h;
参考文献
Peng, Hairuo; Carrico, Dora; Thai, Van; Blaskovich, Michelle; Bucher, Cynthia; Pusateri, Erin E.; Sebti, Said M.; Hamilton, Andrew D.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 9 p. 1768 - 1784
反应条件
1: Et3N / dimethylformamide 2: 80 percent / SOCl2 / dimethylformamide; CH2Cl2 / 0.25 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 4, # 9 p. 1768 - 1784
反应条件
1: Et3N / dimethylformamide 2: 80 percent / SOCl2 / dimethylformamide; CH2Cl2 / 0.25 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 4, # 9 p. 1768 - 1784
反应条件
1: 1.) NaH / 1.) DMF, 20 min., 2.) DMF, RT, 3 h 2: 6N aq. HCl / methanol / 0.5 h / Heating View Scheme
参考文献
Matsui; Sugiura; Nakai; Iguchi; Shigeoka; Takada; Odagaki; Nagao; Ushio; Ohmoto; Iwamura; Yamazaki; Arai; Kawamura
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3307 - 3319
反应条件
hydrogenchloride in ethylene glycol dimethyl ether; water
参考文献
GLAXO GROUP LIMITED
Patent: EP357416 A3, 1990 ;
EP 0357416 A2
