5-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)吲哚啉合成路线 （共 4 条）
反应条件
1: With trifluoroacetic acid in dichloromethane T=20°C; 2 h; 2: With sodium hydrogencarbonate pH=8;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Yan; HU, Yuandong; WANG, Huting; LIU, Yuliang; LI, Jijun; SUN, Deguang; WANG, Zhe; WEI, Yongheng; WANG, Zanping; TANG, Guojing; JING, Lutao
Patent: WO2012/103806 A1, 2012 ;
Location in patent: Page/Page column 48 ;
WO 2012/103806 A1
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dichloromethane; dimethyl sulfoxide T=80°C;
参考文献
Wyeth
Patent: US2008/234262 A1, 2008 ;
Location in patent: Page/Page column 90 ;
反应条件
1.1: potassium carbonate / water; tetrahydrofuran / 2 h / 20 °C 2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 15.5 h / 90 °C / Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 3.2: pH 8 View Scheme
参考文献
WO2012/103806 A1, ;
WO 2012/103806 A1
反应条件
1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 15.5 h / 90 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 2.2: pH 8 View Scheme
参考文献
WO2012/103806 A1, ;
WO 2012/103806 A1
