4-(4-甲基-1-哌嗪基甲基)苯甲酸合成路线 （共 14 条）
反应条件
sodium tetrahydroborate; acetic acid in chloroform T=0 - 20°C; 13 h;
参考文献
Koroleva, Elena V.; Kadutskii, Aleksey P.; Farina, Alexander V.; Ignatovich, Janna V.; Ermolinskaya, Anastasiya L.; Gusak, Klaudiya N.; Kalinichenko, Elena N.
Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5056 - 5058
反应条件
in butan-1-ol T=20°C; 3 - 6 h;
参考文献
MacDonald, Peter; Rossetto, Pierluigi
Patent: US2008/103305 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium hydroxide; water in methanol 1 h; Heating / reflux;
参考文献
ORION CORPORATION
Patent: WO2004/63191 A1, 2004 ;
Location in patent: Page 74 ;
参考文献
WO2004/63191 A1, ;
Page 8 ;
反应条件
1: 1-methyl-piperazine With formic acid 0.25 h; cooling; 2: 4-formyl-benzoic acid T=180 - 200°C; Leuckart-Wallach reaction; 8 h; Further stages.;
参考文献
Ignatovich; Gusak; Chernikhova; Kozlov; Koroleva
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 12 p. 1540 - 1543
反应条件
1.1: trifluoroacetic acid / acetonitrile / 0.25 h / 20 °C 1.2: 20 °C 2.1: hydrogenchloride; water; methanol / 5 h / 60 °C View Scheme
参考文献
WO2011/8788 A1, ;
WO 2011/008788 A1
反应条件
1.1: trifluoroacetic acid / acetonitrile / 0.25 h / 20 °C 1.2: 20 °C 2.1: hydrogenchloride; water; methanol / 5 h / 60 °C View Scheme
参考文献
WO2011/8788 A1, ;
WO 2011/008788 A1
反应条件
2-chloro-1-methyl-pyridinium iodide in dichloromethane T=20°C; 7 h; Product distribution / selectivity;
参考文献
WO2008/98949 A2, ;
Page/Page column 22 ;
WO 2008/098949 A2
反应条件
in methanol; diethyl ether; toluene T=20°C; 21.1667 h;
参考文献
ASTRAZENECA AB
Patent: US2008/153812 A1, 2008 ;
Location in patent: Page/Page column 121 ;
US 20080153812 A1
反应条件
toluene-4-sulfonic acid 48 h; Heating;
参考文献
Sairam; Puranik, Ramachandra; Kelkar, Avijit S.; Sasikiran; Veerender; Parvathi
Synthetic Communications, 2003 , vol. 33, # 20 p. 3597 - 3605
