2-氯-1-(3-氯苯基)-乙醇合成路线 （共 21 条）
反应条件
borane-THF; (S)-3,3-diphenyl-1-methyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborol Yield given. Title compound not separated from byproducts;
参考文献
Ohkuma, Takeshi; Tsutsumi, Kunihiko; Utsumi, Noriyuki; Arai, Noriyoshi; Noyori, Ryoji; Murata, Kunihiko
Organic Letters, 2007 , vol. 9, # 2 p. 255 - 257
反应条件
D-glucose; D-glucose dehydrogenase; NADPH; potassium phosphate buffer; recombinant ketoreductase in water T=20°C; pH=7.0;
参考文献
Zhu, Dunming; Mukherjee, Chandrani; Hua, Ling
Tetrahedron Asymmetry, 2005 , vol. 16, # 19 p. 3275 - 3278
反应条件
Lipozyme TL IM in tert-butyl methyl ether T=40°C; 12 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Xia, Shi Wen; Lin, Hui; Chen, Yong Zheng
Chinese Chemical Letters, 2012 , vol. 23, # 3 p. 289 - 292
反应条件
1: sulfuryl chloride 2: Rhodotorula glutinis var. dairenensis carbonyl reductase; NADPH; potassium phosphate / H2O; dimethylsulfoxide / 30 °C / pH 6.5 View Scheme
参考文献
Bloom, Jonathan D.; Dutia, Minu D.; Johnson, Bernard D.; Wissner, Allan; Burns, Michael G.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3081 - 3084
反应条件
halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; Dehydrochlorination; pH=7.5; Title compound not separated from byproducts;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
Lipozyme TL IM in tert-butyl methyl ether T=40°C; 48 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Xia, Shi Wen; Lin, Hui; Chen, Yong Zheng
Chinese Chemical Letters, 2012 , vol. 23, # 3 p. 289 - 292
反应条件
1: 25 percent / LiClO4; NH4Cl / acetonitrile / 4 h / 80 °C 2: halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer / H2O / 30 °C / pH 7.5 View Scheme
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
Lipozyme TL IM in tert-butyl methyl ether T=40°C; 12 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Xia, Shi Wen; Lin, Hui; Chen, Yong Zheng
Chinese Chemical Letters, 2012 , vol. 23, # 3 p. 289 - 292
反应条件
halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; Dehydrochlorination; pH=7.5; Title compound not separated from byproducts;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
Lipozyme TL IM in tert-butyl methyl ether T=40°C; 48 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Xia, Shi Wen; Lin, Hui; Chen, Yong Zheng
Chinese Chemical Letters, 2012 , vol. 23, # 3 p. 289 - 292
