2-氯-1-(3-氯苯基)-乙醇合成路线 （共 21 条）
反应条件
epoxide hydrolase from Agrobacterium radiobacter AD1; halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; kinetic resolution; pH=7.5;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
sodium hydroxide in water; toluene T=40°C; 3 h;
参考文献
Kizaki, Noriyuki; Sawa, Ikuo; Yano, Miho; Yasohara, Yoshihiko; Hasegawa, Junzo
Bioscience, Biotechnology and Biochemistry, 2005 , vol. 69, # 1 p. 79 - 86
反应条件
halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; Dehydrochlorination; pH=7.5; Title compound not separated from byproducts;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
Lipozyme TL IM in tert-butyl methyl ether T=40°C; 12 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Xia, Shi Wen; Lin, Hui; Chen, Yong Zheng
Chinese Chemical Letters, 2012 , vol. 23, # 3 p. 289 - 292
反应条件
halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; Dehydrochlorination; pH=7.5; Title compound not separated from byproducts;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
Lipozyme TL IM in tert-butyl methyl ether T=40°C; 48 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Xia, Shi Wen; Lin, Hui; Chen, Yong Zheng
Chinese Chemical Letters, 2012 , vol. 23, # 3 p. 289 - 292
反应条件
epoxide hydrolase from Agrobacterium radiobacter AD1; halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; kinetic resolution; pH=7.5;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; Dehydrochlorination; pH=7.5; Title compound not separated from byproducts;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
Lipozyme TL IM in tert-butyl methyl ether T=40°C; 48 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Xia, Shi Wen; Lin, Hui; Chen, Yong Zheng
Chinese Chemical Letters, 2012 , vol. 23, # 3 p. 289 - 292
反应条件
sodium hydroxide in water; toluene
T=40°C; 3 h;
参考文献
Kizaki, Noriyuki; Sawa, Ikuo; Yano, Miho; Yasohara, Yoshihiko; Hasegawa, Junzo
Bioscience, Biotechnology and Biochemistry, 2005 , vol. 69, # 1 p. 79 - 86
