4-甲氧基-2-(三氟甲基)苯甲醛合成路线 （共 3 条）
反应条件
1: 3-trifluoromethyl-4-bromo-1-methoxy-benzene With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.5 h; Inert atmosphere; 2: 1-piperidinecarboxaldehyde in tetrahydrofuran; pentane T=-78 - 20°C; Inert atmosphere;
参考文献
Synthesis, , # 12 art. no. T20108SS, p. 2040 - 2060
反应条件
n-butyllithium; bromine; iron 1.) CCl4, -60 deg C, 2 h, 2.) Et2O, -55 deg C; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 1 p. 72 - 83
反应条件
1: With boron tribromide in dichloromethane T=-78 - 20°C; 2: With water in dichloromethane
参考文献
FOREST LABORATORIES HOLDINGS LIMITED; SARMA, Pakala Kumara, Savithru; ACHARYA, Vinod, Parameshwaran; KASIBHATLA, Srinivas, Rao; TIWARI, Atul; REDDY, Vantaddu, Nagarjuna; BISCHOFF, Alexander
Patent: WO2010/127208 A1, 2010 ;
Location in patent: Page/Page column 53 ;
