2-亚甲基环丙烷-1,1-二羧酸二乙酯合成路线 （共 5 条）
反应条件
potassium tert-butylate in tert-butyl alcohol 0.25 h; Heating;
参考文献
WAYNE STATE UNIVERSITY; The Regents of the University of Michigan
Patent: US2005/113393 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
1: NBS; dibenzoyl peroxide / CCl4 / 1.5 h / Heating; irradiation 2: 23 percent / t-BuOK / 2-methyl-propan-2-ol / 0.25 h / Heating View Scheme
参考文献
Ullmann
Journal of the American Chemical Society, 1959 , vol. 81, p. 5386,5387, 5392
反应条件
potassium tert-butylate; tert-butyl alcohol
参考文献
Ullmann
Journal of the American Chemical Society, 1959 , vol. 81, p. 5386,5387, 5392
反应条件
1.1: aq. NaOH; NaBH4 / ethanol / 0.25 h 2.1: aq. KMnO4 / 2 h / cooling 2.2: 70 percent / aq. H2O2 / tetrahydrofuran / 1.17 h 3.1: 63 percent / (i-Pr)2NEt / toluene / 24 h / 85 - 89 °C View Scheme
参考文献
Yan, Zhaohua; Kern, Earl R.; Gullen, Elizabeth; Cheng, Yung-Chi; Drach, John C.; Zemlicka, Jiri
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 91 - 99
参考文献
Ullmann
Journal of the American Chemical Society, 1959 , vol. 81, p. 5386,5387, 5392
