1: With potassium carbonate; palladium diacetate; triphenylphosphine in ethylene glycol dimethyl ether; water T=20°C; 24 h; Inert atmosphere; 2: With hydrogenchloride in ethylene glycol dimethyl ether; water

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C 1.3: 20 °C / pH 2 2.1: potassium carbonate / triphenylphosphine; palladium diacetate / ethylene glycol dimethyl ether; water / 24 h / 20 °C / Inert atmosphere View Scheme