2-氧代哌啶-1-羧酸苄酯合成路线 （共 14 条）
反应条件
sodium hydride in tetrahydrofuran T=25°C; 5 h;
参考文献
Masse, Julien; Langlois, Nicole
Heterocycles, 2009 , vol. 77, # 1 p. 417 - 432
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; acetonitrile pH=3; 3 h;
参考文献
Ranganathan; Muraleedharan; Bhattacharyya; Kundu
Journal of the Indian Chemical Society, 1998 , vol. 75, # 10-12 p. 583 - 589
反应条件
1: NaBH4 / methanol / 0.25 h / 0 °C 2: 5.34 g / H2SO4 / tetrahydrofuran / 1 h / 20 °C 3: 76 percent / oxone(R); K2CO3 / H2O; acetone / 2 h / 20 °C View Scheme
参考文献
Takeuchi, Yasuo; Azuma, Kumiko; Abe, Hitoshi; Sasaki, Kenji; Harayama, Takashi
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 7 p. 1011 - 1012
反应条件
magnesium 1.) THF, 2.) -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille
Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234
反应条件
1: With diethylaluminium chloride in hexane; dichloromethane T=-78°C; 0.166667 h; 2: With methyl-phenyl-thioether in hexane; dichloromethane T=25°C; 1 h;
参考文献
Tsujimoto, Takashi; Murai, Akio
Synlett, 2002 , # 8 p. 1283 - 1284
反应条件
hydrogen; acetic acid; palladium monocarbide in ethanol
参考文献
Eli Lilly and Company; COR Therapeutics Inc.
Patent: US6291469 B1, 2001 ;
反应条件
in tetrahydrofuran T=-78°C; 3 h;
参考文献
Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille
Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234
反应条件
in tetrahydrofuran
T=-78°C; 3 h;
参考文献
Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille
Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234
反应条件
1.1: KHMDS / tetrahydrofuran; toluene / 1.5 h / -78 °C
1.2: 80 percent / tetrahydrofuran; toluene / 2 h / -78 - 20 °C
2.1: 85 percent / (Ph3P)2PdCl2; Ph3P; K2CO3 / dioxane / 7 h / 90 °C
View Scheme
参考文献
Occhiato, Ernesto G.; Lo Galbo, Fabrizio; Guarna, Antonio
Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7324 - 7330
反应条件
1: 89 percent / LiEt3BH / tetrahydrofuran / 1 h / -78 °C
2: 95 percent / Sc(OTf)3 / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Okitsu; Suzuki; Kobayashi
Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 809 - 823
