N-Boc-D-苯丙氨醇合成路线 （共 33 条）
反应条件
1: With triethylamine in tetrahydrofuran T=0°C; 0.25 h; Inert atmosphere; 2: With sodium tetrahydroborate in tetrahydrofuran; water T=0 - 20°C; Inert atmosphere;
参考文献
Chang, Shaohua; Zhang, Zhang; Zhuang, Xiaoxi; Luo, Jinfeng; Cao, Xianwen; Li, Honglin; Tu, Zhengchao; Lu, Xiaoyun; Ren, Xiaomei; Ding, Ke
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1208 - 1212
反应条件
diisobutylaluminium hydride in hexane; dichloromethane T=20°C; Reduction; 3 h;
参考文献
Tamamura, Hirokazu; Yamashita, Masaki; Nakajima, Yutaka; Sakano, Kyoko; Otaka, Akira; Ohno, Hiroaki; Ibuka, Toshiro; Fujii, Nobutaka
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 2983 - 2996
反应条件
in dichloromethane T=0 - 20°C;
参考文献
PHENEX PHARMACEUTICALS AG; KINZEL, Olaf; GEGE, Christian; STEENECK, Christoph; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2013/64231 A1, 2013 ;
Location in patent: Page/Page column 61 ;
WO 2013/064231 A1
反应条件
sodium hydroxide; trifluoroacetic acid; palladium monocarbide in methanol; water
反应条件
sodium hydroxide in dichloromethane; water T=20°C; 24 h;
参考文献
Ji, Haitao; Li, Huiying; Martasek, Pavel; Roman, Linda J.; Poulos, Thomas L.; Silverman, Richard B.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 3 p. 779 - 797
反应条件
1: D-(+)-Phenylalanine With lithium aluminium tetrahydride in tetrahydrofuran 6 h; HeatingReflux; 2: With water; sodium hydroxide in tetrahydrofuran T=0 - 20°C; 0.5 h; 3: di-tert-butyl dicarbonate in tetrahydrofuran; dichloromethane; water
参考文献
WO2011/26781 A1, ;
Page/Page column 77-78 ;
WO 2011/026781 A1
反应条件
hydrogen; {(1,5-cyclooctadiene)Rh(1,2-bis((2S,5S)-2,5-diethylphospholano)benzene)}triflate in tetrahydrofuran T=20 - 25°C; Catalytic hydrogenation; P=1551.44 Torr; 12 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
反应条件
sodium in tetrahydrofuran; water
参考文献
US5190974 A1, ;
US 5190974 A
反应条件
caesium carbonate in methanol 3 h; Ambient temperature;
参考文献
Iwama; Katsumura
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 12 p. 3363 - 3365
反应条件
sodium hydroxide in methanol; water Ambient temperature;
参考文献
Hyun, Seung Il; Kim, Young Gyu
Tetrahedron Letters, 1998 , vol. 39, # 24 p. 4299 - 4302
