N-Boc-D-苯丙氨醇合成路线 （共 33 条）
反应条件
1: 99 percent / lithium borohydride; trimethylsilyl chloride / tetrahydrofuran / 0.25 h / 20 °C 2: 95 percent / CHCl3 / 0 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 16 p. 5037 - 5042
反应条件
porcine pancreatic lipase in hexane; toluene T=37°C; pH=7; 3 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Magrioti, Victoria; Fotakopoulou, Irene; Athinaios, Nicolaos; Anastasopoulou, Panoula; Constantinou-Kokotou, Violetta; Kokotos, George
Letters in Organic Chemistry, 2010 , vol. 7, # 2 p. 159 - 162
反应条件
1: 9.15 g / diisopropylethylamine / CH2Cl2 / 2 h 2: 13.61 g / imidazole / dimethylformamide / 6 h 3: 12.40 g / LiBH4 / tetrahydrofuran / 1.5 h / 35 °C 4: 68 percent / PPh3, diisopropylazodicarboxylate / tetrahydrofuran; acetonitrile / 24 h / Ambient temperature 5: CuBr-SMe2 / tetrahydrofuran; diethyl ether / 1 h / -40 °C 6: Bu4NF / tetrahydrofuran / 1 h / 4 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 51 p. 9389 - 9392
反应条件
1: base 2: LiAlH4 / tetrahydrofuran 3: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
反应条件
1: base 2: LiAlH4 / tetrahydrofuran 3: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
反应条件
1: LiAlH4 / tetrahydrofuran 2: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
反应条件
1: 85 percent / H2 / Pd(OH)2 / methanol / 7 h / Ambient temperature; different cis-2,3-disubstituted chiral aziridines 2: KOH / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 50 p. 9193 - 9196
反应条件
1: 62 percent / LAH / tetrahydrofuran 2: 82 percent / NaOH / methanol; H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 24 p. 4299 - 4302
反应条件
potassium hydroxide in ethanol Yield given;
参考文献
Tetrahedron Letters, , vol. 39, # 50 p. 9193 - 9196
反应条件
1: 13.61 g / imidazole / dimethylformamide / 6 h 2: 12.40 g / LiBH4 / tetrahydrofuran / 1.5 h / 35 °C 3: 68 percent / PPh3, diisopropylazodicarboxylate / tetrahydrofuran; acetonitrile / 24 h / Ambient temperature 4: CuBr-SMe2 / tetrahydrofuran; diethyl ether / 1 h / -40 °C 5: Bu4NF / tetrahydrofuran / 1 h / 4 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 51 p. 9389 - 9392
