N-Boc-D-苯丙氨醇合成路线 （共 33 条）
反应条件
1: 12.40 g / LiBH4 / tetrahydrofuran / 1.5 h / 35 °C 2: 68 percent / PPh3, diisopropylazodicarboxylate / tetrahydrofuran; acetonitrile / 24 h / Ambient temperature 3: CuBr-SMe2 / tetrahydrofuran; diethyl ether / 1 h / -40 °C 4: Bu4NF / tetrahydrofuran / 1 h / 4 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 51 p. 9389 - 9392
反应条件
1: 68 percent / PPh3, diisopropylazodicarboxylate / tetrahydrofuran; acetonitrile / 24 h / Ambient temperature 2: CuBr-SMe2 / tetrahydrofuran; diethyl ether / 1 h / -40 °C 3: Bu4NF / tetrahydrofuran / 1 h / 4 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 51 p. 9389 - 9392
反应条件
1: CuBr-SMe2 / tetrahydrofuran; diethyl ether / 1 h / -40 °C 2: Bu4NF / tetrahydrofuran / 1 h / 4 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 51 p. 9389 - 9392
反应条件
1: LAH / tetrahydrofuran 2: 82 percent / NaOH / methanol; H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 24 p. 4299 - 4302
反应条件
1: Et3N, DMAP / CH2Cl2 / 9 h / Ambient temperature 2: 75 percent / NaBH4, MeOH / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 4 p. 1275 - 1294
反应条件
1: 79 percent / BF3*OEt2, CuCN / tetrahydrofuran / 1.5 h / -30 °C 2: Et3N, DMAP / CH2Cl2 / 9 h / Ambient temperature 3: 75 percent / NaBH4, MeOH / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 4 p. 1275 - 1294
反应条件
1: triethylamine / dichloromethane / 24 h / 25 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 22, # 1 p. 366 - 373
参考文献
Hyun, Seung Il; Kim, Young Gyu
Tetrahedron Letters, 1998 , vol. 39, # 24 p. 4299 - 4302
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-60°C; Swern Oxidation; 0.166667 h; Cooling with acetone-dry ice; 2: t-butyl (1R)-1-benzyl-2-hydroxyethylcarbamate in dichloromethane T=-60°C; 0.25 h; 3: With N-ethyl-N,N-diisopropylamine in dichloromethane T=-60°C; 0.0833333 h;
参考文献
MENARINI RICERCHE S.P.A.
Patent: WO2004/94412 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
1: RuCl3, NaIO4 2: potassium hydrogen carbonate / dimethylformamide / Ambient temperature View Scheme
参考文献
Matsunaga, Hirofumi; Ishizuka, Tadao; Kunieda, Takehisa
Tetrahedron, 1997 , vol. 53, # 4 p. 1275 - 1294
