3-溴-5-氯吡啶-4-羧醛合成路线 （共 2 条）
反应条件
1: 3-bromo-5-chloro-pyridine With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; Inert atmosphere; 2: formic acid ethyl ester in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C;
参考文献
Gibson, Christoph; Schnatbaum, Karsten; Pfeifer, Jochen R.; Locardi, Elsa; Paschke, Matthias; Reimer, Ulf; Richter, Uwe; Scharn, Dirk; Faussner, Alexander; Tradler, Thomas
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4370 - 4379
反应条件
1: 3-bromo-5-chloro-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran 0.5 h;
参考文献
NOVARTIS AG; ALLAN, Martin; CHAMOIN, Sylvie; HU, Qi-Ying; IMASE, Hidetomo; PAPILLON, Julien
Patent: WO2011/61168 A1, 2011 ;
Location in patent: Page/Page column 66 ;
WO 2011/061168 A1
