1: phenylphosphoric acid dichloride; alanine isopropyl ester hydrochloride With 1-methyl-1H-imidazole in dichloromethane T=-5 - 5°C; 1.5 h; 2: β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine in dichloromethane T=0 - 20°C; 5 h; ConcentrationTemperatureTime;

1: β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine With 1,1-dimethylethylmagnesium chloride in tetrahydrofuran T=20°C; 0.5 h; 2: 2(S)-[(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester in tetrahydrofuran T=20°C; 72 h;

hydrogenchloride in di-isopropyl ether; water T=22°C; 72 h;