1: 3-(1-{[3,4-dichloro-5-(methyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-yl]carbonyl}-4-piperidinyl)-1,3-oxazolidin-2-one / N,N-dimethyl-formamide / 1 h / 60 °C 2: sodium hydroxide / methanol / 4 h / 50 °C 3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C 4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C View Scheme

in acetonitrile T=80°C; 48 h; Inert atmosphere;