5-氨基-3-甲基-1H-吡唑-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
sodium hydride in tetrahydrofuran T=0 - 20°C; 2.5 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2006/32518 A1, 2006 ;
Location in patent: Page/Page column 200 ;
WO 2006/032518 A1
反应条件
1: (5-methyl-1H-pyrazol-3-yl)amine With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 2 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/219195 A1, 2007 ;
Location in patent: Page/Page column 55 ;
US 20070219195 A1
反应条件
potassium hydroxide in dichloromethane; water T=20°C; 18 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/117051 A1, 2008 ;
Location in patent: Page/Page column 28 ;
WO 2008/117051 A1
参考文献
Lloyd, Gareth O.; Steed, Jonathan W.
Soft Matter, 2011 , vol. 7, # 1 p. 75 - 84
