(s)-3-boc-氨基丁酸甲酯合成路线 （共 15 条）
反应条件
sodium hydroxide in methanol T=20°C; Hydrolysis; 18 h;
参考文献
Yang, Hua; Jurkauskas, Valdas; Mackintosh, Nicole; Mogren, Tobias; Stephenson, Corey R. J.; Foster, Katherine; Brown, William; Roberts, Edward
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 800 - 808
参考文献
F. HOFFMANN-LA ROCHE AG; HENDRICKS, Robert, Than; HERMANN, Johannes, Cornelius; JAIME-FIGUEROA, Saul; KONDRU, Rama, K.; LOU, Yan; LYNCH, Stephen, M.; OWENS, Timothy, D.; SOTH, Michael; YEE, Calvin, Wesley
Patent: WO2011/144585 A1, 2011 ;
Location in patent: Page/Page column 214 ;
WO 2011/144585 A1
反应条件
silver benzoate; triethylamine
T=20°C; Rearrangement; esterification; 18 h;
参考文献
Yang, Hua; Jurkauskas, Valdas; Mackintosh, Nicole; Mogren, Tobias; Stephenson, Corey R. J.; Foster, Katherine; Brown, William; Roberts, Edward
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 800 - 808
反应条件
Candida antarctica lipase B in toluene
T=45°C; 0.75 h;
参考文献
Flores-Sanchez, Patricia; Escalante, Jaime; Castillo, Edmundo
Tetrahedron Asymmetry, 2005 , vol. 16, # 3 p. 629 - 634
反应条件
1: 56 percent / p-toluenesulfonic acid / toluene / 24 h / Heating
2: hydrogen / [Rh(o-((2S,5S)-2,5-diethylphospholan-1-yl)2C6H4)(COD)]BF4 / methanol / 25 °C / 22501.8 Torr
View Scheme
参考文献
Heller, Detlef; Holz, Jens; Komarov, Igor; Drexler, Hans-Joachim; You, Jingsong; Drauz, Karheinz; Boerner, Armin
Tetrahedron Asymmetry, 2002 , vol. 13, # 24 p. 2735 - 2741
反应条件
1: 56 percent / p-toluenesulfonic acid / toluene / 24 h / Heating
2: hydrogen / [Rh(o-((2S,5S)-2,5-diethylphospholan-1-yl)2C6H4)(COD)]BF4 / methanol / 25 °C / 22501.8 Torr
View Scheme
参考文献
Heller, Detlef; Holz, Jens; Komarov, Igor; Drexler, Hans-Joachim; You, Jingsong; Drauz, Karheinz; Boerner, Armin
Tetrahedron Asymmetry, 2002 , vol. 13, # 24 p. 2735 - 2741
反应条件
1: 1.) 9-BBN, 2.) H2O2, NaOH / 1.) THF
2: 61 percent / PDC / dimethylformamide
3: diethyl ether
View Scheme
参考文献
Alcon, Montserrat; Canas, Marc; Poch, Marta; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1994 , vol. 35, # 10 p. 1589 - 1592
反应条件
1: 61 percent / PDC / dimethylformamide
2: diethyl ether
View Scheme
参考文献
Alcon, Montserrat; Canas, Marc; Poch, Marta; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1994 , vol. 35, # 10 p. 1589 - 1592
反应条件
1: 4-DMAP / CH2Cl2
2: 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine
3: 1.) 9-BBN, 2.) H2O2, NaOH / 1.) THF
4: 61 percent / PDC / dimethylformamide
5: diethyl ether
View Scheme
参考文献
Alcon, Montserrat; Canas, Marc; Poch, Marta; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1994 , vol. 35, # 10 p. 1589 - 1592
反应条件
1: Et3N / tetrahydrofuran / 0.33 h / -10 °C
2: diethyl ether; tetrahydrofuran / 18 h / 20 °C
3: 96 percent / silver benzoate; Et3N / 18 h / 20 °C
View Scheme
参考文献
Yang, Hua; Jurkauskas, Valdas; Mackintosh, Nicole; Mogren, Tobias; Stephenson, Corey R. J.; Foster, Katherine; Brown, William; Roberts, Edward
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 800 - 808
