bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; sodium 2-ethyl hexanoate in water; ethyl acetate T=20°C; 5 h; Inert atmosphereLarge scale reaction;

<b>Multi-step reaction with 4 steps<br /> </b>1: aq. NaHCO₃ / acetone / 4 h / 60 &deg;C<br />2: Et₃N / CH₂Cl₂ / 0.17 h / -20 &deg;C<br />3: triethyl phosphite / xylene / 11 h / Heating<br />4: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: triethyl phosphite / xylene / 11 h / Heating<br />2: AcOH, tetra-n-butylammonium fluoride / tetrahydrofuran / 8.5 h / 50 &deg;C<br /> <br /> &nbsp;