4,6-二甲氧基-2-(1-哌嗪)嘧啶合成路线 （共 4 条）
反应条件
sodium hydroxide in methanol (20 ml)-water
参考文献
Mitsubishi Pharma Corporation
Patent: US6455528 B1, 2002 ;
反应条件
potassium carbonate in acetonitrile T=20°C;
参考文献
Ge, Hai-Xia; Wang, Li-Chen; Jiang, Zhen-Zhou; Ni, Sheng-Liang
Arzneimittel-Forschung/Drug Research, 2006 , vol. 56, # 10 p. 673 - 677
反应条件
in ethanol 1.) ice bath, 2.) room temperature;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
1: 30percent aq. H2O2, HCOOH / Ambient temperature 2: 48.6 percent / ethanol / 1.) ice bath, 2.) room temperature View Scheme
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
