1: 90 percent / Al-Hg / tetrahydrofuran 2: 90 percent / hydrogenolysis 3: 60 percent / Cu, i-Pr2NEt, DMF / various solvent(s) / 130 °C 4: Et3SiH-trifluoroacetic acid / CH2Cl2 / 0 - 20 °C 5: acetic acid 6: 68 percent / MeC(CH2OH)3, KOH / methanol 7: 75 percent / 0.01 M aq. KOH / aq. KOH View Scheme

Multi-step reaction with 2 steps 1: 90 percent / Al-Hg / tetrahydrofuran2: 90 percent / hydrogenolysis  

Multi-step reaction with 5 steps 1: 90 percent / Al-Hg / tetrahydrofuran2: 90 percent / hydrogenolysis3: 60 percent / Cu, i-Pr2NEt, DMF / various solvent(s) / 130 °C4: Et3SiH-trifluoroacetic acid / CH2Cl2 / 0 - 20 °C5: acetic acid