1: 60 percent / Cu, i-Pr2NEt, DMF / various solvent(s) / 130 °C 2: Et3SiH-trifluoroacetic acid / CH2Cl2 / 0 - 20 °C 3: acetic acid 4: 68 percent / MeC(CH2OH)3, KOH / methanol 5: 75 percent / 0.01 M aq. KOH / aq. KOH View Scheme

Multi-step reaction with 2 steps 1: 90 percent / Al-Hg / tetrahydrofuran2: 90 percent / hydrogenolysis  

Multi-step reaction with 3 steps 1: 60 percent / Cu, i-Pr2NEt, DMF / various solvent(s) / 130 °C2: Et3SiH-trifluoroacetic acid / CH2Cl2 / 0 - 20 °C3: acetic acid