4-氯-6-甲基噻吩[2,3-D]嘧啶合成路线 （共 4 条）
反应条件
N,N-dimethyl-formamide; trichlorophosphate in 1,2-dichloro-ethane 1.5 h; Heating;
参考文献
Kaplina, N. V.; Grinev, A. N.; Bogdanova, G. A.; Alekseeva, L. M.; Pushkina, T. V.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 126 - 129
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 197 - 200
反应条件
1: 73 percent / 2 h / Heating 2: 82 percent / phosphorus oxychloride, DMF / 1,2-dichloro-ethane / 1.5 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 2 p. 126 - 129
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 2 p. 197 - 200
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid in tetrachloromethane 1.5 h; Heating;
参考文献
Kaplina, N. V.; Grinev, A. N.; Bogdanova, G. A.; Alekseeva, L. M.; Pushkina, T. V.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 126 - 129
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 197 - 200
反应条件
potassium carbonate in N,N-dimethyl-formamide
0.166667 h; Heating;
参考文献
Golub, Andriy G.; Bdzhola, Volodymyr G.; Briukhovetska, Nadiia V.; Balanda, Anatoliy O.; Kukharenko, Olexander P.; Kotey, Igor M.; Ostrynska, Olga V.; Yarmoluk, Sergiy M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 870 - 876
