1: phenyl-magnesium bromide With Cu(I)[(CH3CN)4]BF4; tri-n-butyl phosphite in diethyl ether; dichloromethane T=-10°C; 0.5 h; Inert atmosphere; 2: ethynyl-4-methyl-1,3-dioxolan-2-one in diethyl ether; dichloromethane T=-10°C; 2 h; Inert atmosphere; regioselective reaction;

o-nitrobenzenesulfonyl hydrazide; lanthanum trifluoromethanesulphonate in acetonitrile T=20°C; 24 h; Inert atmosphere;

1: phenyl-magnesium bromide With zinc(II) chloride in tetrahydrofuran T=0°C; 2: 1-ethynyl-1-methyloxirane With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 3: With ammonium chloride in tetrahydrofuran

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.75 h / -78 °C / Inert atmosphere 1.2: 2.2 h / -78 - 20 °C / Inert atmosphere 1.3: 1.5 h / 0 - 20 °C / Inert atmosphere 2.1: o-nitrobenzenesulfonyl hydrazide; lanthanum trifluoromethanesulphonate / acetonitrile / 24 h / 20 °C / Inert atmosphere View Scheme