hydrogenchloride; hydrazine hydrate 1.) 95 percent ethanol, reflux, 2 h, 2.) room temperature; Multistep reaction;

hydrogenchloride; hydrazine hydrate 1.) 95 percent ethanol, reflux, 2 h, 2.) room temperature; Multistep reaction;

1.1: PPh3; DEAD; chloroacetic acid / tetrahydrofuran / 1.5 h / 0 °C 1.2: 406.4 mg / Na2CO3 / methanol / 2 h / 20 °C 2.1: NH2NH2*H2O / methanol / Heating 3.1: Na2CO3 / H2O / 0 - 20 °C 4.1: CAL-B / tetrahydrofuran / 3 h / 30 °C / Enzymatic reaction 5.1: 74 percent / formic acid / Pd/C / methanol View Scheme