5-溴噻唑并[5,4-b]吡啶-2-基氨基甲酸叔丁酯合成路线 (共 2 条)
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 5 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2009/129211 A1, 2009 ;
Location in patent: Page/Page column 35; 37 ;
WO 2009/129211 A1
反应条件
1: bromine; acetic acid / 100 °C / Cooling with ice 2: triethylamine / 4-(N,N-dimethlyamino)pyridine / acetone / 50 °C View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2426135 A1, 2012 ;