1: glycine With pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide; sodium methylate; nickel(II) nitrate hexahydrate in methanol 0.333333 h; Heating; 2: 1-iodo-n-hexane With sodium hydroxide; (R)-NOBIN in dichloromethane T=20°C; 1 h; 3: With hydrogenchloride in methanol; water Heating;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 10 p. 1948 - 1951
meso-2,6-D-diaminopimelic acid dehydrogenase mutant BC621; ammonium chloride; NADPH in various solvent(s) 24 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 128, # 33 p. 10923 - 10929