3-磺酰氨基乙酸甲酯-2-噻吩甲酸甲酯合成路线 （共 6 条）
反应条件
pyridine 4 h; Ambient temperature;
参考文献
Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682
反应条件
1: 210 g / 1.) sodium bisulfite, NaOH, CuCl, 2.) KCl / H2O / 16 h / 143 °C 2: POCl3, PCl5 / 1.5 h / Heating 3: 95 percent / CHCl3 / 3 h / Heating 4: 71 percent / pyridine / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 4 p. 678 - 682
反应条件
1: 95 percent / CHCl3 / 3 h / Heating 2: 71 percent / pyridine / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 4 p. 678 - 682
反应条件
sodium methylate in methanol; hexane 6 h; Heating;
参考文献
Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682
反应条件
1: 58 percent / CH3ONa / methanol; hexane / 6 h / Heating 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h 3: 75 percent / xylene / 7 h / Heating View Scheme
参考文献
Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682
反应条件
1: 58 percent / CH3ONa / methanol; hexane / 6 h / Heating 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 16 h View Scheme
参考文献
Binder, Dieter; Hromatka, Otto; Geissler, Franz; Schmied, Karl; Noe, Christian R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 678 - 682
