1-溴-4-(2,2,2-三氟乙氧基)苯合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20 - 120°C; 6 h; Inert atmosphere;
参考文献
VIAMET PHARMACEUTICALS, INC.; HOEKSTRA, William J.; SCHOTZINGER, Robert J.; RAFFERTY, Stephen W.
Patent: WO2013/109998 A1, 2013 ;
Location in patent: Page/Page column 41 ;
反应条件
potassium carbonate in acetone T=20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/822 A1, 2005 ;
Location in patent: Page/Page column 44 ;
WO 2005/000822 A1
反应条件
1: ortho-bromo-phenol With sodium hydroxide in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; 2: 2,2,2-trifluoroethyl methanesulphonate in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=140°C; 5 h; Microwave radiation;
参考文献
Dublanchet, Anne-Claude; Compere, Delphine; Cluzeau, Philippe; Blais, Stephane; Denis, Alexis; Ducrot, Pierre; Courte, Karine; Descamps, Sophie
Patent: US2004/72871 A1, 2004 ;
Location in patent: Page/Page column 23 ;
反应条件
1: 80 percent / tin, 12M HCl / acetic acid / RT, 10 min; reflux, 1 h 2: 1.) conc. HBr, NaNO2, 2.) copper(I) bromide, cc. HBr / 1.) H2O, 5 deg C, 2.) H2O, reflux, 2 h View Scheme
参考文献
Bartmann, E.; Dorsch, D.; Finkenzeller, U.
Molecular Crystals and Liquid Crystals (1969-1991), 1991 , vol. 204, p. 77 - 89
反应条件
HNO2; copper(I) bromide Multistep reaction;
参考文献
Emsley, James W.; Celebre, Giorgio; Luca, Giuseppina De; Longeri, Marcello; Catalano, Donata; Veracini, Carlo Alberto
Gazzetta Chimica Italiana, 1996 , vol. 126, # 7 p. 429 - 434
反应条件
n-butyllithium; sodium chloride; acetic acid in tetrahydrofuran; carbon tetrachloride-hexane; hexane; water
参考文献
Ortho Pharmaceutical Corporation
Patent: US4864032 A1, 1989 ;
