(2S)-2-羟基-3-苯基丙腈合成路线 (共 5 条)
反应条件
TiCl2(OPri)2; (2R,3R)-TADDOL in toluene T=-78°C; 20 h; Title compound not separated from byproducts;
参考文献
Minamikawa, Hiroyuki; Hayakawa, Satoshi; Yamada, Tohru; Iwasawa, Nobuharu; Narasaka, Koichi
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 12 p. 4379 - 4384
反应条件
acetate buffer in diethyl ether T=23°C; 18 h; oxynitrilase; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ognyanov, Vassil I.; Datcheva, Violeta K.; Kyler, Keith S.
Journal of the American Chemical Society, 1991 , vol. 113, # 18 p. 6992 - 6996
反应条件
anhydrous trisodium citrate; citric acid T=0 - 5°C; 1 h; (S)-hydroxynitrile lyase from Hevea brasiliensis;
参考文献
Schmidt, Michael; Herve, Stephanie; Klempier, Norbert; Griengl, Herfried
Tetrahedron, 1996 , vol. 52, # 23 p. 7833 - 7840
反应条件
lipase PS-30 in diethyl ether T=15°C; 20 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Xu, Qing; Xie, Yongli; Geng, Xiaohong; Chen, Peiran
Tetrahedron, 2010 , vol. 66, # 3 p. 624 - 630
反应条件
1: phenylacetaldehyde With (1R,2R)-cyclohexane-1,2-diylbis(2-azaethenyl-3-tert-butyl-2-hydroxybenzo-5-sulfonic acid) disodium salt; Manganese (II) acetate in methanol T=20°C; 0.5 h; 2: sodium cyanide in methanol T=20°C; 24 h; optical yield given as percent ee;
参考文献
Qu, Yanyang; Jing, Linhai; Wu, Zhiqing; Wu, Di; Zhou, Xiangge
Tetrahedron Asymmetry, 2010 , vol. 21, # 2 p. 187 - 190