4-氨基-3-溴苯甲酸甲酯合成路线 （共 11 条）
反应条件
N-bromosuccinmide in chloroform T=0°C; 3 h;
参考文献
LG LIFE SCIENCES LTD.; CHOI, Sung Pil; KIM, Geun Tae; SONG, Jeong Uk; KIM, Tae Hun; LIM, Dong Chul; KANG, Seung Wan; KIM, Hyung Jin
Patent: WO2010/93191 A2, 2010 ;
Location in patent: Paragraph 1365-1368 ;
WO 2010/093191 A2
反应条件
sulfuric acid 20 h; Reflux;
参考文献
Suzuki, Yamato; Oishi, Shinya; Takei, Yoshinori; Yasue, Misato; Misu, Ryosuke; Naoe, Saori; Hou, Zengye; Kure, Tatsuhide; Nakanishi, Isao; Ohno, Hiroaki; Hirasawa, Akira; Tsujimoto, Gozoh; Fujii, Nobutaka
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 25 p. 4907 - 4915
反应条件
in tetrahydrofuran; methanol 3 h;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1886 - 1898
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium carbonate in N,N-dimethyl-formamide T=100°C; Suzuki coupling; 20 h; Inert atmosphere;
参考文献
Kayser-Bricker, Katherine J.; Glenn, Matthew P.; Lee, Sang Hoon; Sebti, Said M.; Cheng, Jin Q.; Hamilton, Andrew D.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 4 p. 1764 - 1771
反应条件
lithium hydroxide; water in tetrahydrofuran
参考文献
Kayser-Bricker, Katherine J.; Glenn, Matthew P.; Lee, Sang Hoon; Sebti, Said M.; Cheng, Jin Q.; Hamilton, Andrew D.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 4 p. 1764 - 1771
反应条件
dihydroxyborane; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=100°C; Suzuki Coupling;
参考文献
UNIVERSITY OF SOUTH FLORIDA; YALE UNIVERSITY
Patent: WO2008/70823 A2, 2008 ;
Location in patent: Page/Page column 5; 10-11; 9/14 ;
WO 2008/070823 A2
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine in 1,4-dioxane 5 h; Reflux;
参考文献
Journal of Organic Chemistry, , vol. 75, # 2 p. 468 - 471
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=100°C; 16 h; Inert atmosphere;
参考文献
Wang, Fei; Cai, Shangjun; Wang, Zhipeng; Xi, Chanjuan
Organic Letters, 2011 , vol. 13, # 12 p. 3202 - 3205
反应条件
iodine; potassium iodide; sodium nitrite Inert atmosphere;
参考文献
Garcia-Fortanet, Jorge; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 42 p. 8108 - 8111
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 1.25 h / 0 °C 1.2: 24 h / 0 - 20 °C / Darkness 2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere View Scheme
参考文献
Suzuki, Yamato; Oishi, Shinya; Takei, Yoshinori; Yasue, Misato; Misu, Ryosuke; Naoe, Saori; Hou, Zengye; Kure, Tatsuhide; Nakanishi, Isao; Ohno, Hiroaki; Hirasawa, Akira; Tsujimoto, Gozoh; Fujii, Nobutaka
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 25 p. 4907 - 4915
