4-(3-甲基-3-丁烯-1-基)氯苯合成路线 (共 2 条)
反应条件
1: 3-chloro-2-methyl-propene With magnesium in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: p-bromomethylchlorobenzene in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Watanabe, Eiichi; Kaiho, Atsushi; Kusama, Hiroyuki; Iwasawa, Nobuharu
Journal of the American Chemical Society, 2013 , vol. 135, # 32 p. 11744 - 11747
反应条件
ethyl bromide; iodine; magnesium; copper(I) bromide 1.) diethyl ether, 25-30 deg C, 5 h; 2.) THF, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 11 p. 4653 - 4662