3-Boc氨基-4-氯吡啶合成路线 (共 1 条)
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / |Inert atmosphere; |Schlenk technique
1.2: 2 h / 0 - 20 °C / |Inert atmosphere; |Schlenk technique
2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / |Inert atmosphere; |Schlenk technique
3.1: potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex / tert-butyl alcohol / 5 h / 110 °C / |Schlenk technique; |Inert atmosphere
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参考文献
Wilson, Robert J.; Rosenberg, Adam J.; Kaminsky, Lauren; Clark, Daniel A.
Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2203 - 2212