(±)-2,5-二氨基戊酸 单盐酸盐合成路线 （共 16 条）
反应条件
hydrogenchloride 15 h; Heating;
参考文献
Prabhakaran; Woo; Yorgey; Gould
Journal of the American Chemical Society, 1988 , vol. 110, # 17 p. 5785 - 5791
反应条件
hydrogenchloride; acetic acid in water T=100°C;
参考文献
Martinkus; Tann; Gould
Tetrahedron, 1983 , vol. 39, # 21 p. 3493 - 3505
反应条件
thionyl chloride in methanol
参考文献
Meiji Seika Kaisha, Ltd.
Patent: EP1227083 A1, 2002 ;
反应条件
hydrogenchloride in methanol T=30 - 35°C;
参考文献
Winter; Graudums; Frankus
1983 , vol. NO. 11, p. 2021 - 2028
反应条件
thionyl chloride T=0°C; 8 h; Reflux;
参考文献
Shengule, Sudhir R.; Karuso, Peter
Australian Journal of Chemistry, 2014 , vol. 67, # 2 p. 184 - 191
反应条件
in sodium hydroxide; water
参考文献
Biontex Laboratories GmbH
Patent: US6281371 B1, 2001 ;
反应条件
1: SOCl2 / 14 h / Ambient temperature 2: H2O / 50 - 60 °C / brief heating View Scheme
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1867639 A1, 2007 ;
Location in patent: Page/Page column 92 ;
反应条件
sodium hydroxide 1.) H2O, reflux, 2.) H2O, pH=9.8, RT, 3 d; Yield given. Multistep reaction;
参考文献
Martinkus; Tann; Gould
Tetrahedron, 1983 , vol. 39, # 21 p. 3493 - 3505
反应条件
Streptomyces clavuligerus; examination of incorporation by labelled <5-(14)C, 5-(3)H>ornithine;
参考文献
Bycroft, Barrie W.; Penrose, Audrey; Gillett, Janet; Elson, Stephen W.
Journal of the Chemical Society, Chemical Communications, 1988 , # 14 p. 980 - 981
反应条件
1.1: thionyl chloride / 8 h / 0 °C / |Reflux 2.1: hydrogenchloride; sodium amalgam / water / 0 °C / pH 1 - 3 2.2: 2 h / 95 °C / pH 4.5 3.1: triethylamine / ethanol View Scheme
参考文献
Shengule, Sudhir R.; Karuso, Peter
Australian Journal of Chemistry, 2014 , vol. 67, # 2 p. 184 - 191
