(±)-2,5-二氨基戊酸 单盐酸盐合成路线 （共 16 条）
反应条件
1: SOCl2 / 14 h / Ambient temperature 2: H2O / 50 - 60 °C / brief heating View Scheme
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1867639 A1, 2007 ;
Location in patent: Page/Page column 92 ;
反应条件
dipotassium peroxodisulfate; osmium; potassium meta-periodate; silver nitrate; potassium hydroxide in water T=24.84°C; 3 h; Inert atmosphereClosed vessel; MechanismKineticsThermodynamic data; TemperatureConcentrationSolvent;
参考文献
Malode, Shweta J.; Abbar, Jyothi C.; Nandibewoor, Sharanappa T.
Inorganica Chimica Acta, 2010 , vol. 363, # 11 p. 2430 - 2442
反应条件
1.1: thionyl chloride / 8 h / 0 °C / |Reflux
2.1: hydrogenchloride; sodium amalgam / water / 0 °C / pH 1 - 3
2.2: 2 h / 95 °C / pH 4.5
View Scheme
参考文献
Shengule, Sudhir R.; Karuso, Peter
Australian Journal of Chemistry, 2014 , vol. 67, # 2 p. 184 - 191
反应条件
1: SOCl2 / 14 h / Ambient temperature
2: H2O / 50 - 60 °C / brief heating
3: 96 percent / acetonitrile / 3.67 h / Heating
View Scheme
参考文献
Oklobdzija; Comisso; Decorte; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1329 - 1334
反应条件
N-bromosuccinmide in water
1) ice-cooling, 1.5 h; 2) reflux, 5 min;
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
