1: 47 percent / potassium t-butoxide / 2-methyl-propan-2-ol / 3 h / Heating 2: 38 percent / pyridine, phenyl dichlorophosphate / 1,2-dimethoxy-ethane / 18 h View Scheme

potassium tert-butylate in tert-butyl alcohol 3 h; Heating;

1: 47 percent / potassium t-butoxide / 2-methyl-propan-2-ol / 3 h / Heating 2: 1) sodium bis(2-methoxyethoxy)aluminium hydride; 2) sodium hydroxide (2 M) / 1) toluene, 24 h; 2) ethanol, <10 deg C 3: H2 / palladium-on-carbon (10percent) / ethanol / 3.5 h View Scheme

1: 47 percent / potassium t-butoxide / 2-methyl-propan-2-ol / 3 h / Heating 2: 49 percent / sodium hydrogen carbonate / dimethylformamide / 24 h View Scheme

1: 47 percent / potassium t-butoxide / 2-methyl-propan-2-ol / 3 h / Heating 2: 1) sodium bis(2-methoxyethoxy)aluminium hydride; 2) sodium hydroxide (2 M) / 1) toluene, 24 h; 2) ethanol, <10 deg C View Scheme