4-苄基-5-氧代-3-吗啉甲酸合成路线 （共 9 条）
反应条件
sodium hydroxide in water 0 deg C, 30 min, 30-33 deg C, 2 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2577 - 2580
反应条件
potassium tert-butylate in tert-butyl alcohol 3 h; Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2577 - 2580
反应条件
1: 1) sodium hydroxide (2 M); 2) sodium borohydride / 1) 30 min; 2) 6-10 deg C, 1+1+1+2 h 2: 24 percent / sodium hydroxide / CH2Cl2; H2O / 0 deg C, r.t., 2 h 3: 47 percent / potassium t-butoxide / 2-methyl-propan-2-ol / 3 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2577 - 2580
反应条件
1: 24 percent / sodium hydroxide / CH2Cl2; H2O / 0 deg C, r.t., 2 h 2: 47 percent / potassium t-butoxide / 2-methyl-propan-2-ol / 3 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2577 - 2580
反应条件
methanol; sodium hydroxide; water Product distribution / selectivity;
参考文献
WO2008/119685 A2, ;
Page/Page column 33 ;
WO 2008/119685 A2
反应条件
pyridine; phenylphosphoric acid dichloride in ethylene glycol dimethyl ether 18 h;
参考文献
Brown, George R.; Foubister, Alan J.; Wright, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2577 - 2580
反应条件
1: 1) sodium bis(2-methoxyethoxy)aluminium hydride; 2) sodium hydroxide (2 M) / 1) toluene, 24 h; 2) ethanol, <10 deg C 2: H2 / palladium-on-carbon (10percent) / ethanol / 3.5 h View Scheme
参考文献
Brown, George R.; Foubister, Alan J.; Wright, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2577 - 2580
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide 24 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2577 - 2580
反应条件
dimethylsulfide borane complex; triethylamine in tetrahydrofuran T=0°C; 16 h; Heating / reflux;
参考文献
UCB S.A.
Patent: WO2006/114606 A1, 2006 ;
Location in patent: Page/Page column 58-59 ;
WO 2006/114606 A1
